- Title
- Pathologic complete response (pCR) and survival of women with inflammatory breast cancer (IBC): an analysis based on biologic subtypes and demographic characteristics
- Creator
- Biswas, Tithi; Jindal, Charulata; Fitzgerald, Timothy L.; Efird, Jimmy T.
- Relation
- International Journal of Environmental Research and Public Health Vol. 16, Issue 1, no. 124
- Publisher Link
- http://dx.doi.org/10.3390/ijerph16010124
- Publisher
- MD PIAG
- Resource Type
- journal article
- Date
- 2019
- Description
- In this US-based study of the National Cancer Database (NCDB), we examined 8550 patients diagnosed with non-metastatic, invasive inflammatory breast cancer (IBC) who received surgery from 2004-2013. Patients were grouped into four biologic subtypes (HR+/HER 2- , HR+/HER2+ , HR-/HER 2+, HR-/HER2-). On average, women were 56 years of age at diagnosis and were followed for a median of 3.7 years. The majority were white (80%), had private health insurance (50%), and presented with poorly differentiated tumors (57%). Approximately 46% of the cancers were >5 cm. Most patients underwent mastectomy (94%) and received radiotherapy (71%). Differences by biologic subtypes were observed for grade, lymph node invasion, race, and tumor size (p < 0.0001). Patients experiencing pathologic complete response (pCR, 12%) vs. non-pCR had superior 5-year overall survival (OS) (77% vs. 54%) (p < 0.0001). Survival was poor for triple-negative (TN) tumors (37%) vs. other biologic subtypes (60%) (p < 0.0001). On multivariable analysis, TN-IBC, positive margins, and not receiving either chemotherapy, hormonal therapy or radiotherapy were independently associated with poor 5-year survival (p < 0.0001). In this analysis of IBC, categorized by biologic subtypes, we observed significant differential tumor, patient and treatment characteristics, and OS.
- Subject
- biologic subtypes; diagnosis; inflammatory breast cancer; pCR; survival; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1454914
- Identifier
- uon:45020
- Identifier
- ISSN:1661-7827
- Rights
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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Goal 3: Good Health and Well-Being
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